Unmet Needs of Adolescents with Moderate to Severe Atopic Dermatitis in the TARGET DERM Registry
نویسندگان
چکیده
منابع مشابه
Dupilumab treatment in adults with moderate-to-severe atopic dermatitis.
BACKGROUND Dupilumab, a fully human monoclonal antibody that blocks interleukin-4 and interleukin-13, has shown efficacy in patients with asthma and elevated eosinophil levels. The blockade by dupilumab of these key drivers of type 2 helper T-cell (Th2)-mediated inflammation could help in the treatment of related diseases, including atopic dermatitis. METHODS We performed randomized, double-b...
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The primary action of leukotrienes includes contraction of human airway muscle, chemotaxis, and increased vascular permeability, with secondary effects of inhibiting allergen-induced early and late responses. Although there is limited available information and research regarding leukotrienes in atopic dermatitis (AD), there is evidence to support their role in the pathogenesis of the disease. W...
متن کاملMontelukast in the Treatment of Children with Moderate-to-severe Atopic Dermatitis: a Pilot Study
severity, HDM-specific IgE, and CD30 are significantly decreased with occlusive bed covers, however, there was not a statistically significant difference between the study populations. Additionally, HDM allergen in this study was not common and may not be an important factor in the disease process of this population. Future studies should include participants with both sensitization and signifi...
متن کاملPersistence of mild to moderate atopic dermatitis.
IMPORTANCE Atopic dermatitis (AD) is a common illness of childhood. OBJECTIVE To evaluate the natural history of AD and determine the persistence of symptoms over time. DESIGN, SETTING, AND PARTICIPANTS A cross-sectional and cohort study of a nation-wide long-term registry of children with AD enrolled in the Pediatric Eczema Elective Registry (PEER). MAIN OUTCOMES AND MEASURES Self-report...
متن کاملEfficacy and safety of topically applied tacrolimus ointment in patients with moderate to severe atopic dermatitis.
BACKGROUND Tacrolimus is a T-cell-selective cytokine inhibitor. The topical formulation was specifically developed for treating inflammatory skin diseases, including atopic dermatitis (AD). The purpose of this study was to evaluate the efficacy and safety of topically applied tacrolimus ointment (Protopic) in treating Taiwanese patients with moderate to severe AD. METHODS This was an open-lab...
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ژورنال
عنوان ژورنال: Skin
سال: 2023
ISSN: ['2574-1624']
DOI: https://doi.org/10.25251/skin.7.supp.207